Plasma polymer barrier layers to control the release kinetics from dissolvable microneedle patches

Dissolving microneedles are a noninvasive transdermal drug delivery platform that offers painless needle-free patient treatment. Current strategies to control the kinetics of release from polymeric microneedle patches consist adjusting bulk polymer formulations and/or encapsulating cargo in controlled vehicles. Instead, this study, rates were altered by modifying surface properties using plasma coatings with tailored properties. The main advantage one-step, solvent-free, and scalable method is it can be applied any type regardless their or material. Octadiene films found suppress burst effect otherwise rapidly dissolving reduce dissolution rate factor four compared uncoated patches. approach presented study an alternative, highly tunable, customizable strategy for controlling